ABSTRACT
Objective :To explore serum level of amino-terminal propepitide of type Ⅲ procollagen (PⅢNP) in pa-tients with arrhythmia and its correlation with other clinical indexes .Methods :A total of 135 patients with arrhyth-mia ,who were treated in our department from Apr 2014 to Apr 2017 ,were selected as arrhythmia group .Another 89 healthy subjects undergoing physical examination simultaneously were enrolled as healthy control group .Accord-ing to NYHA cardiac function classification ,arrhythmia group was further divided into class I group (n＝37) ,classⅡ group (n＝39) and class Ⅲ ～ Ⅳ group (n＝59).Serum levels of BNP and PⅢNP ,left ventricular end-diastolic di-mension (LVEDd) ,left ventricular end-systolic dimension (LVESd) and LVEF were measured and compared among all groups.Correlation among serum P Ⅲ NP ,BNP levels and cardiac function indexes were analyzed in these pa-tients .Results :Compared with healthy control group ,there were significant rise in serum levels of BNP [ (1132. 88 ± 32.84) μg/L vs .(1984.63 ± 84.61) μg/L] and PⅢ NP [ (26.44 ± 5.89) ng/ml vs.(52.51 ± 10.85) ng/ml] , LVEDd [ (53.38 ± 4.81) mm vs.(62.12 ± 5.35) mm] and LVESd [ (41.23 ± 5.93) mm vs.(53.19 ± 6.86) mm] , and significant reduction in LVEF [(49.85 ± 4.57)% vs.(34.83 ± 4.53)%] in arrhythmia group ,P＝0.001 all.A-long with cardiac function class rose ,there were significant rise in serum levels of BNP [(1242.68 ± 36.71) μg/Lvs. (1481.83 ± 46.09) μg/Lvs.(1938.39 ± 51.94) μg/L] and PⅢNP [ (34.36 ± 5.92) ng/ml vs .(47.81 ± 6.35) ng/ml vs .(60.94 ± 6.74) ng/ml] ,and class I group＜class Ⅱ group＜class Ⅲ ～ Ⅳ group ,P＝0.001 all.Pearson corre-lation analysis indicated that serum P ⅢNP level were significant positively correlated with LVEDd and LVESd ( r＝0.329 ,0.463 ,P＝0.043 ,0.029) ,and significant inversely correlated with LVEF (r＝ －0.351 ,P＝0.036).Con-clusion : The serum PⅢNP level rises in patients with arrhythmia ,it is significantly correlated with ventricular struc-ture and cardiac function indexes .